![]() ![]() doi: 10.1016/0927-7757(94)03028-XĪslam M, Fu L, Su M, Vijayamohanan K, Dravid VP (2004) Novel one-step synthesis of amine-stabilized aqueous colloidal gold nanoparticles. doi: 10.1021/la9036309Īlexandridis P, Hatton TA (1995) Poly(ethylene oxide)-poly(propylene oxide)-poly (ethylene oxide) block copolymer surfactants in aqueous solutions and at interfaces: thermodynamics, structure, dynamics, and modeling. The high stability, proven biocompatibility, and imaging properties of gold–Pluronic core–shell nanoparticles hold promise for relevant intracellular applications, with such a design providing the feasibility to combine all multiple functionalities in one nanoparticle for simultaneous detection and imaging.Ībdullin TI, Bondar OV, Shtyrlin YG, Kahraman M, Culha M (2010) Pluronic block copolymer-mediated interactions of organic compounds with noble metal nanoparticles for SERS analysis. Furthermore, dark-field cellular imaging demonstrated that gold–Pluronic nanoparticles were able to be efficiently uptaken by cells, being internalized through nonspecific endocytosis. ![]() Cytotoxicity tests showed no modification of cellular viability in the presence of properly purified particles. The obtained gold–Pluronic core–shell nanoparticles proved to be highly stable in salted solution. The formation and phase-transfer of gold nanoparticles were analyzed by UV–Vis absorption spectroscopy, transmission electron microscopy, and dynamic light scattering. Uniform, 9–10-nm-sized, hydrophobic gold nanoparticles were synthesized in organic phase by reducing gold salt with oleylamine, after which oleylamine-protected gold nanoparticles were phase-transferred into aqueous medium using Pluronic F127 block copolymer, resulting in gold–Pluronic core–shell nanoparticles with a mean hydrodynamic diameter of ~35 nm. ![]() This study presents the synthesis of gold–Pluronic core–shell nanoparticles by a two-step method and investigates their biological impact on cancer cells, specifically nanoparticle internalization and cytotoxicity. ![]()
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